摘要
目的探讨化疗联合重组人p53腺病毒或沙培林治疗恶性胸腔积液的疗效。方法 96例恶性胸腔积液患者分为两组,在常规GP方案化疗的基础上,抽胸水后一组用重组人p53腺病毒胸腔注入,另一组应用沙培林胸腔注入,观察二者疗效和副作用。结果治疗组与对照组疗效无明显差异,治疗组有效率71.7%;但二者的副作用具有明显差异,今又生组的局部不良反应胸痛和咳嗽加重明显小于沙培林组。结论应用重组人p53腺病毒治疗恶性胸腔积液安全有效,而副作用比沙培林低。
Objective To explore curative effect of combination of rAd-p53 or group A streptococcus and chemotherapy in treatment of malignant pleural effusion.Methods 96 patients with malignant pleural effusion were divided into therapy group and control group randomly.On the basis of gemcitabine and cisplatin chemotherapy,46 patients were treated with rAd-p53 by intrapleural injection in treatment group.50 patients were treated with group A streptococcus by intrapleural injection in control group.Result The changes in volume ofpleural effusion and treatment side effects were observed in two groups.There was no obvious difference of effective rate between the two groups（P0.05）,but the side effects of treatment group was obvious lower than that of control group,include chest ache and cough increasing.Conclusion The intrapleural injection with rAd-p53 is simple and effective in treatment ofmalignant pleural effusion,and its side effects is lower than that of group A streptococcus.
出处
《中国医药指南》
2011年第22期5-7,共3页
Guide of China Medicine
基金
广州市医药卫生科技项目(2008-YB-154)
