摘要
目的观察超选择动脉插管＋顺铂联合5-氟脲嘧啶方案化疗在局部肿块直径≥4 cm的Ⅱa一Ⅲb期宫颈癌治疗中的疗效。方法分析35例肿瘤直径≥4cm的Ⅱa一Ⅲb期宫颈癌患者根治术前给予子宫动脉灌注化疗，观察肿块缩小程度、后续治疗及随访情况。结果完全缓解22例，部分缓解10例，总有效率91．4％，手术成功率81．3％；介入化疗后手术再辅以放化疗患者中位生存期15（6—38）个月；介入化疗后再行放化疗患者中位生存期12（3～38）个月。结论超选择动脉插管＋顺铂联合5-氟脲嘧啶方案化疗作为术前辅助化疗对局部晚期宫颈癌患者是安全有效的。
Objective To investigate the efficacy of cisplatin and 5-fluorouracil with super-selective arterial cannulation in chemotherapy of cervical cancer with local tumor diameter ≥ 4cm at stage II a-lllb. Methods 35 cases of cervical cancer with tumor diameter≥4cm at stage Ⅱ a-Ⅲ b received uterine artery infusion chemotherapy before radical surgery to observe the diminished extent of tumor, successive treatment and follow-up. Results Complete remission was achieved in 22 cases, and partial remission in 10 cases. The total effective rate was 91.4% and the success rate of operation was 81.3%. The median survival time of cases operated and assisted with chemotherapy after interventional chemotherapy was 15 months （6-38 months）, and that of those only receiving chemotherapy after interventional chemotherapy was 12 months （3-38 months）. Conclusion Super-selective arterial and cisplatin and 5-fluorouracil regimen is safe and effective as preoperative chemotherapy for locally advanced cervical cancer patients.
出处
《中国妇幼健康研究》
2011年第4期537-539,共3页
Chinese Journal of Woman and Child Health Research
关键词
超选择性动脉插管
宫颈癌
血管造影
化疗
super-selective arterial cannulation
cervical cancer
angiography
chemotherapy
