摘要
目的:观察急性痛风性关节炎关节液的基质金属蛋白酶(MMP-3)的变化及当归拈痛汤对MMP-3的影响,探讨其疗效的作用机理及环节。方法:治疗组采用当归拈痛汤治疗3个月。采用ELISA法检测患者治疗前后血清MMP-3水平,并设正常对照组观察。结果:与正常对照组比较,MMP-3值明显升高,当归拈痛汤治疗后血清MMP-3水平明显下降。治疗组临床总有效率89.4%。结论:当归拈痛汤能有效降低急性痛风性关节炎血清MMP-3水平,对急性痛风件关节炎有较好的防治作用。
Objective： To observe the change of serum matrix metalloproteinase （MMP-3） levels in acute gouty arthritis patients and explore the effect of mechanism of angelica Niantong decoction. Methods： Treatment group was treated with angelica Niantong decoction for 3 months. Serum MMP-3 levels were measured by ELISA, at the same time, normal control group was also set up. Results： Compared with normal control group, serum MMP-3 levesls significantly increased in treatment group, but reduced after angelica Niantong decoction Treatment. The total effective rate in treatment group was 89.4%. Conclusion： Angelica Niantong decoction could effectively reduce serum MMP-3 levels in acute gouty arthritis patients and which also plays a good role in the prevention and treatment of acute gouty arthritis.
出处
《中医临床研究》
2011年第13期42-44,共3页
Clinical Journal Of Chinese Medicine
关键词
痛风性关节炎
当归拈痛汤
基质金属蛋白酶-3
Acute gouty arthritis
Angelica Niantong decoction
Matrix metalloproteinase-3
