摘要
目的:检测大肠癌患者术中应用化疗药物后,手术前后血清CEA和CA19-9的变化,确定其对预防大肠癌微转移,降低术后复发率和死亡率的临床意义。方法:采用ELISA方法测定30例术中应用化疗药物大肠癌患者及30例术中未应用化疗药物大肠癌患者手术前后外周血中CEA和CA19-9含量的变化,同时选用30例非肿瘤人群作为正常对照。结果:60例大肠癌患者(Duck C期)术前外周血CEA,CA19-9均值高于正常值(60.73±25.99mg/L vs 2.67±1.643 mg/L,P<0.01;112.73±78.76 kU/L vs 14.6±6.68 kU/L,P<0.01)。30例术中应用化疗药物的大肠癌患者手术后血清CEA、CA l9-9下降较快(术后7d:7.96±3.32 mg/L,29.34±11.05 kU/L,P<0.01vs术前),术中未应用化疗药物组的大肠癌患者术后血清CEA和CA19-9下降缓慢(术后7d:34.23±20.59 mg/L,88.12±32.28 kU/L,P>0.05 vs术前)。结论:通过定量检测大肠癌患者外周血CEA和CA19-9的含量,证明手术中温热灌注化疗+动脉化疗以及术后联合化疗的辅助治疗是十分必要的,对预防大肠癌微转移,降低术后复发率和死亡率有重要的临床意义。
Objective：To observe the pre-and post-operational changes of serum carcinoembryonic antigen（CEA）and carbohydrate antigen 19-9（CA19-9） in patients with progressive colorectal cancer and their clinical significances.Methods：The serum levels of CEA and CA19-9 were detected by indirect enzyme-linked immunosorbent assay（ELISA）in 60 patients（30 cases received chemotherapy during operation while 30 cases did not） diagnosed with colorectal cancer and 30 normal volunteers.Results：The serum levels of CEA and CA19-9 were significantly higher in all the cancer patients before operation than those in the normal controls（60.73±25.99mg/L vs 2.67±1.643mg/L,P0.01;112.73±78.76kU/L vs 14.6±6.68kU/L,P0.01）.CEA and CA19-9 levels were rapidly decreased in the patients received chemotherapy（7d post-operation：7.96±3.32mg/L,29.34±11.05kU/L,P0.01 vs pre-operation）,but they were not significantly decreased in the patients without chemotherapy（7d：post-operation：34.23±20.59mg/L,88.12±32.28kU/L,P0.05 vs pre-operation）.Conclusion：Detection of CEA and CA19-9 in the peripheral blood confirms that portal vein continuous chemotherapy and great volume of intraperitoneal chemotherapy are effective in preventing postoperative metastasis of colorectal cancer.
出处
《黑龙江医药》
CAS
2011年第3期392-394,共3页
Heilongjiang Medicine journal
关键词
大肠癌
术中化疗
癌胚抗原
糖类抗原19-9
colorectal cancer
intraperitoneal chemotherapy
carcinoembryonic antigen
carbohydrate antigen 19-9
