摘要
目的观察血液灌流对维持性血液透析患者难治性高血压的疗效并探讨其可能机制。方法选取68例维持性血液透析难治性高血压患者，随机分为治疗组（34例）与对照组（34例）。对照组应用常规治疗和血液透析，治疗组在常规治疗基础上加用血液灌流治疗。结果治疗组控制血压的程度明显优于对照组，治疗组与对照组治疗后血清内皮素和同型半胱氨酸的表达均下降，但是治疗组下降值明显高于对照组。结论在常规治疗基础上应用血液透析和血液灌流，能较好的纠正维持性血液透析患者的难治性高血压，其治疗作用可能与血液灌流清除血浆中内皮素和同型半胱氨酸有关。
Objective To investigate the clinical effectiveness of blood perfusion for refractory hypertension of patients undergoing maintenance hemodialysis. Methods Sixty-eight patients with refractory hypertension receiving maintenance hemodialysis were selected and randomly divided into two groups：34 in control group with regular treatment and hemodialysis, and 34 in treatment group with regular treatment and blood perfusion. Results Blood pressure control was better in treatment group than in control group. The expression of serum endothelin（ET） and homocysteine（HCY） was both de- creased in treatment group and control group, and in the treatment group that was deceased more significantly. Conclusions Both hemodialysis and blood perfusion on the basis of regular treatment improve the clinical effectiveness in patients with refractory hypertension, which may be associated with the decrease of serum ET and HCY by blood perfusion.
出处
《临床肾脏病杂志》
2011年第6期264-266,共3页
Journal Of Clinical Nephrology
关键词
灌流
肾透析
高血压
内皮素
Perfusion
Renal Dialysis
Hypertension
Endothelins
