摘要
目的制备粒径小、性质稳定、抗菌活性强的纳米银。方法化学合成法制备纳米银,以超滤法将反应体系中的杂质除去得高纯度的纳米银。以紫外分光光度计、透射电子显微镜、激光纳米粒度测定仪对其进行理化表征。结果制备出的纳米银平均粒径为18.29 nm,分布窄;表面带负电荷,平均表面Zeta电位为-36.5 mV;性质稳定,抗菌活性强。结论实验结果表明,本方法可以制备出优良的纳米银。
OBJECTIVE To prepare silver nanoparticles with small particle diameter,good stability and high antimicrobial activity.METHODS The silver nanoparticles were prepared by chemical synthesis using silver nitrate,maltose and ammonia water as the reactants.The main physical properties of silver nanoparticles were characterized by UV spectrophotometer,transmission electron microscope and laser nanoparticle detecter.The bacteriostasis activity was determined by tube dilution method,using silver sulphadiazine as the positive control.RESULTS The mean diameter of the silver nanoparticles was 18.29 nm,and the Zeta potential was-36.5 mV.The silver nanoparticles were steady and had higher bacteriostatic activity than silver sulphadiazine.CONCLUSION The chemical synthesis method can be used to prepare desired silver nanoparticles.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2011年第13期1007-1010,共4页
Chinese Pharmaceutical Journal
基金
国家重大新药创制科技重大专项资助项目(2008ZXJ09004-045)
关键词
纳米银
制备
表征
抗菌
silver nanoparticle
preparation
characterization
antimicrobial
