摘要
细胞凋亡(apoptosis)是一种基因控制的细胞生理性自杀行为,用以维持细胞数量的相对恒定,可由某种刺激或抑制剂的移除而激活。在哺乳动物精子发生过程中,各级生精细胞都会发生相应的凋亡,通过严格调控以确保成熟精子生成的数量和质量。生精细胞的凋亡是一个许多基因参与的复杂的不可逆过程,其中Bcl-2/Bax基因族、p53基因、Fas-Fasl基因、C-myc基因、CREM基因、HSP基因族、c-Kit/SCF基因、Insl3基因、iNOS基因、BMP8B基因、TR基因和存活蛋白(survivin)基因等发挥了重要作用。研究哺乳动物睾丸生精细胞凋亡相关基因,有利于了解生精细胞凋亡机制,为进一步阐明精子发生的调控机制,预防和治疗精子发生相关疾病提供重要的理论依据。
Apoptosis is a physiological process of self-destruction in certain cells that is determined by genes and can be initiated by a stimulus or by removal of a repressor agent,which helps to keep the number of cells relatively constant.During spermatogenesis of mammal,to ensure the quality and quantity of mature sperm,the spermatogenic cells may be optimized via apoptosis with critical regulation.The apoptosis of spermatogenic cells is a sophisticated irreversible process that a lot of genes are involved,such as Bcl-2/Bax gene cluster,p53,Fas-Fasl,C-myc,CREM,HSP gene cluster,c-Kit/SCF,Insl3,iNOS,BMP8B,TR and survivin.Studying and researching the genes associated with apoptosis of spermatogenic cells of mammal is in favor of understanding the mechanism of apoptosis,thus providing important information to further illuminate the regulation mechanism of spermatogenesis,prevent and treat physiological and pathological diseases.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第3期389-394,共6页
Chemistry of Life
基金
河北省卫生厅医学科学研究计划项目(2009173)
河北省计生委科研计划项目(2009-B16)
河北省教育厅自然科学研究计划项目(2009105)
河北大学博士基金项目(2007B06)资助
关键词
生精细胞
凋亡
基因
spermatogenic cells
apoptosis
gene
