摘要
目的:制备盐酸小檗碱脂质体,并对其质量进行评价。方法:采用薄膜分散-pH梯度-探头超声法制备盐酸小檗碱脂质体,测定其包封率和粒径,以透射电镜观察脂质体形态。结果:盐酸小檗碱脂质体平均粒径为(158±5)nm;盐酸小檗碱包封率为91.8%。结论:结果表明脂质体粒径均一,体系稳定。
Objective ： To prepare and evaluate the quality of berberine hydrochloride liposomes. Methods ： Berberine hydrochloride liposome were prepared by film hydration- pH gradient- probe ultrasonic- method and its morphology was examined by the transmission electron microscope. The shape of liposomes, particles size, entrapment efficacy were evaluated. Results ： The average diameter of berberine liposomes were （ 158±5 ） nm.The encapsulation efficiency of berberine liposome was 91.8%. Conclusion ： The results showed that the liposomes have uniform size and encapsulation efficiency is well.
出处
《辽宁中医药大学学报》
CAS
2011年第7期221-223,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
盐酸小檗碱
脂质体
包封率
berberine
liposomes
entrapment efficiency
