摘要
目的探讨上海地区汉族人群血栓素A2受体rs768963基因多态性与血小板聚集功能的关系。方法采用聚合酶链反应-限制片长多态性检测59例脑梗死患者和40名对照者的血栓素A2受体rs768963基因多态性基因型,并且测定血小板聚集率。结果脑梗死组甘油三酯浓度和血压水平明显高于对照组,高密度脂蛋白胆固醇浓度明显低于对照组(P<0.05)。对照组rs768963基因突变型(CT型+CC型)与野生型(TT型)比较,血小板1’聚集率明显升高;脑梗死组rs768963基因突变型与野生型比较,血小板1’聚集率和最大聚集率均明显升高。并且全部研究对象的突变型与野生型比较,血小板1’聚集率和最大聚集率也明显升高(P<0.05)。结论血栓素A2受体rs768963基因突变型的血小板聚集率比野生型明显升高,容易引起血栓形成相关疾病。
Aim To investigate the relationship between the thromboxane A2 receptor（TXA2R） gene polymorphism（rs768963） and platelet aggregation in Han people in Shanghai. Methods TXA2R gene types,tested by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）,as well as platelet aggregation of 59 cerebral infarction patients and 40 health controls were detected. Results Triglyceride（TG） and blood pressure of cerebral infraction group were significantly higher when high density lipoprotein cholesterol（HDLC） was lower than that of health control（P0.05）.Mutant of TXA2R（CT and CC） improves the platelet aggregation（1＇） in health control group and platelet aggregation（1＇ and max） in cerebral infarction group,compared with wild type（TT）.Studied as a whole group,mutant of TXA2R also had more significant impact on the platelet aggregation（1＇ and max） than wild type. Conclusion Compared with wild type,mutant of TXA2R（rs768963） improves the platelet aggregation,which may increase the incidence of thrombosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第6期525-528,共4页
Chinese Journal of Arteriosclerosis
