摘要
目的 :探讨细胞因子在急性胰腺炎中的变化及其临床意义。方法 :检测了 42例急性胰腺炎患者血清肿瘤坏死因子 (TNF)、白细胞介素 6 (IL 6 )及C 反应蛋白 (CRP)。结果 :所有胰腺炎患者在入院第 1、 4天 ,血清肿瘤坏死因子、白细胞介素 6均明显升高 ,尤其是重型患者 ,升高更为明显。CRP在入院第 1天无明显升高 ,第 4天时升高显著。结论 :肿瘤坏死因子α、白细胞介素 6、C 反应蛋白等三种细胞因子参与了急性胰腺炎的发病过程 。
Objective:To study the clinical significance of serum cytokines in patients with acute pancreatitis(AP).Methods:Tumor necrosis factor(TNF α),interleukin 6(IL 6),and C reactive protein(CRP) levels were determined in 42 patients with AP.Results:On the 1st and 4th days after admission all patients with AP and especialy in the severe cases,TNF α、IL 6 levels were elevated significantly than that in normal controls,but the level of C reactive protein did not change on the lst day,It was elevated only following the increasment of TNF α、IL 6 on the 4th day.Conclusion:Cytokines are involved in the pathogenesis of AP.Measurement of serum TNF α、IL 6、CRP levels may be taken as useful markers to diagnose and the prognosis of AP.
出处
《急诊医学》
CSCD
1999年第5期314-315,共2页
