摘要
目的：制备[BMIM]PF6-MnO2-CHIT/GCE修饰电极,研究酚磺乙胺（ETH）在该电极上的电化学行为及其测定方法。方法：循环伏安法和微分脉冲伏安法。结果：ETH在[BMIM]PF6-MnO2-CHIT/GCE上的循环伏安图上出现1对灵敏、可逆的氧化还原峰,其氧化峰电流响应是其在MnO2-CHIT/GCE上的2.8倍,峰电位差降低到0.029 V,电子转移速率常数Ks=0.283 s-1。ETH在[BMIM]PF6-MnO2-CHIT/GCE上的微分脉冲伏安扫描峰电流与其浓度在5.0×10-7~5.0×10-4mol.L-1范围内呈良好的线性关系,检出限为5.0×10-8mol.L-1。连续5次测定1.0×10-5mol.L-1酚磺乙胺溶液的RSD为1.8%。结论：本法可靠、快捷、灵敏,可用于酚磺乙胺注射液中酚磺乙胺含量的电化学定量测定,结果满意。
Objective：To fabricate PF6-MnO2-CHIT/GCE modified electrode,the electrochemical behavior and determination of ethamsylate（ETH） on the electrode were investigated.Methods：Cyclic voltammetry and differential pulse voltammetry.Results：The cyclic voltammetry curves of ETH at PF6-MnO2-CHIT/GCE electrode present a pair of sensitive and reversible redox peaks.The peak current response at the proposed electrode enhances 2.8 folds higher than that at the MnO2-CHIT/GCE,and the peak potential difference is down to 0.029 V,electron transfer rate constant was Ks=0.283 S-1.The differential pulse voltammetry peak current of ETH in PF6-MnO2-CHIT/GCE showed good linear relationship in the range of ETH concentration of 5.0×10-7-5.0×10-4 mol·L-1,with a detection limit of 5.0×10-8 mol·L-1.The relative standard deviation of 1.0×10-5 mol·L-1 ETH was 1.8% for 5 consecutive measurements.Conclusion：The proposed method can be applied in ETH electrochemical determination with fast speed,high sensitivity and satisfied results.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2011年第6期1171-1174,共4页
Chinese Journal of Pharmaceutical Analysis
基金
河南省高校青年骨干教师基金(001135)
河南省教育厅自然科学研究基金(2008B150006)资助项目
