3Klokkers-Bethke K, Fischer W. Development of multiple unit drug delivery system for positioned release in the gastrointestinal tract [J]. J Controlled Release,1991, 15(1):105-112.
4Davis SS, Hardy JG, Fara JW. Transit of pharmaceutical dosage forms through the small intestine [J].Gut, 1986, 27(8):886-892.
5Ishibashi T, Pitcaim GR, Yoshino H, et al. Scintigraphic evaluation of a new vapsule-type colon specific drug delivery system in health volunteers[J]. J Pharm Sci, 1998, 87(5):531-534.
6Evans DF, Pye G, Bramley R, et al. Measurments of gastrointestinal pH profiles in normal ambulant human subjects[J]. Gut, 1988, 29(8):1035-1041.
7朱盛山.药物制剂新剂型[M].北京:化学工业出版社,2003:239—250.
8SINHA V R, KUMRIA R. Microbially triggered drug delivery tothe colon[J]. Eur J Pharm Sci,2003, 18(1):3-18.
9MURAOKEA M,HU Z,SHIMOKAWA T,et al.Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers[J]. Controlled Release, 1998, 52(1/2): 119-129.
10ISHIBASHI T ,PITCAIRN G R,YOSHINO H,et al.Scintigraphic evaluation of a new capsule-type colons pecific drug delivery system in healthy volunteer[J]. J Pharm Sci,1998,87(5) :531-535.