摘要
目的探讨HBV前S1(PreS1)抗原与乙型肝炎肝脏炎症程度的关系及其在判断拉米夫定抗病毒疗效中的作用。方法将116例慢性乙型肝炎患者随机分为治疗组(58例,一般护肝治疗+拉米夫定)及对照组(58例,一般护肝治疗),采用酶联免疫吸附法(ELISA)对患者血清标本进行PreS1抗原测定,分析PreS1抗原与转氨酶之间的关系,并动态测定两组患者血清PreS1抗原阴转率并与HBVDNA做对比分析。结果 PreS1抗原阳性患者转氨酶水平明显高于阴性者(P<0.05);拉米夫定治疗慢性乙型肝炎患者不同疗程PreS1抗原阴转率与HBVDNA一致;拉米夫定治疗组PreS1抗原阴转率明显高于对照组(P<0.05)。结论 PreS1可反映乙型肝炎炎症活动情况,并能预测拉米夫定抗病毒疗效,具有良好的临床应用价值。
Objective To investigate the relation between PreS1 antigen and liver function change in hepatitis B patients with lamivudine.Methods 116 chronic hepatitis B patients were randomly divided into combination group （n=58,treated with the union of hepatoprotective and lamivudine）and control group （n=58,treated with only）.Serum tramsaminase and PreS1 in all patients were detected by ELISA, HBV DNA quantity was detected by PCR, the relations were analyzed dynamically in both groups. Results The concentration of serum transaminase in patients with positive PreS1 antigen was higher than that in negative group（P0.05）;PreS1 antigen undetectable rate of patients who were treated with lamivudine was consistent with HBV DNA;The positive rate of PreS1 antigen in combination group was higher than that in control group（P0.05）.Conclusion PreS1 antigen was not only sensitive in reflecting the hapatic inflammatory level, but also valuable in predicting antiviral effects of lamivudine.
出处
《肝脏》
2011年第2期100-102,共3页
Chinese Hepatology
基金
福建省龙海市科技局基金资助项目(2009042)
关键词
前S1抗原
慢性乙型肝炎
病毒复制
肝脏炎症
拉米夫定
PreS1 antigen
Chronic hepatitis B
Viral replication
Hepatic inflammation
Lamivudine
