摘要
目的探讨2型糖尿病患者C反应蛋白（CRP）、糖基化血红蛋白（HbA1c）与踝肱动脉指数（ABI）的相关性。方法对205例2型糖尿病住院患者进行临床参数检测及胸部X线片、腹部B超、双下肢血管彩超、心电图、肌电图等检查,检测患者的CRP、HbA1c和ABI,对可能的影响因素进行分析。结果不同性别餐后2小时血糖（2hPG）、胆固醇（TC）、高密度脂蛋白（HDL-c）、载脂蛋白A（APOA）、载脂蛋白B（APOB）、脂蛋白a（LPa）、吸烟率、血尿酸（UA）等差异有统计学意义（P〈0.05）。单因素分析结果显示：在男性患者中,ABI与CRP呈负相关（r=-0.241,P=0.029）,在女性患者中ABI与CRP等无相关性;在≥60岁年龄组的患者中,ABI与CRP有相关性;在病程1.25~6.00年患者中,ABI与CRP呈负相关。偏相关分析结果显示：在控制年龄、性别、病程和2hPG后,CRP和ABI呈负相关（r=-0.337,P=0.003）,但未见HbA1c与ABI存在相关性。结论在2型糖尿病患者中,CRP与ABI存在负相关,在治疗及预后中应密切关注这两个指标的变化。
Objective To explore the correlation between the C-reactive protein（CRP）,glycosylated hemoglobin（HbA1c） with the index of ankle brachial artery（ABI）.Methods 205 patients with type 2 diabetes mellitus hospitalized for clinical parameters according to the conventional methods were checked by detection and chest X-ray,abdomen B-sonography,double lower limbs vascular sufficiency,electrocardiogram,electromyography examination,and the detection of patients with the ABI,and possible influential factors were analyzed.Results There were significant difference with the 2-hr plasma glucose（2hPG）,cholesterol（TC）,high-density lipoprotein（HDL-c）,apolipoprotein A（APOA）,apolipoprotein B（APOB）,lipoproteins A（LPa）,smoking,blood serum uric acid（UA） in various gender（P〈0.05）.Single factor analysis result showed：in male patients,ABI and CRP presented negative correlation（r=-0.241,P=0.029）,in female patients,CRP and ABI had no correlation in age above of 60 years patients with ABI correlations between CRP,during the course of 1.25~6.00 years,visible ABI and CRP had negative correlation.Partial correlation analysis showed that：in the control of age,gender,duration,and 2hPG,CRP and ABI presented negative correlation（r=-0.337,P=0.003）,but has not seen the HbA1c and ABI correlativity.Conclusion In type 2 diabetes patients CRP and ABI exists negative correlation,we should pay close attention to the two indexes to change in treatment and prognosis.
出处
《安徽医科大学学报》
CAS
北大核心
2011年第5期455-458,共4页
Acta Universitatis Medicinalis Anhui
关键词
糖尿病
2型
C反应蛋白
diabetes mellitus
type 2
C-reactive protein
