摘要
目的 研究醛氢叶酸（ＬＶ）联合氟尿嘧啶（５ＦＵ） 系列方案治疗晚期结直肠癌近期疗效和毒性。 方法 ９３ 例分别接受下列化疗①Ａ（ＬＦ） 组：５ＦＵ（５００ ｍｇ／ｍ２·ｄ－ １） 加ＬＶ（２０ ｍｇ／ｍ２·ｄ－ １） 静脉连续５ｄ，３ 周重复；②Ｂ（ＬＦＰ） 组：将顺铂（ＰＤＤ４０ ｍｇ／ｄ 静脉连续３ｄ） 加入Ａ 组中；③Ｃ（ＬＦＨ） 组：将羟基喜树碱（ＨＣＰＴ６ ～８ ｍｇ／ｍ２·ｄ－ １ 静脉连续５ ～１０ｄ） 加入Ａ 组中。每例２ 疗程后作疗效、不良反应评价。 结果 有效率分别为Ａ组１２５ ％（５／４０）、Ｂ组２２２％ （６／２７） 和Ｃ组３４６ ％（９／２６），Ｃ组显著高于Ａ组（ Ｐ＜ ００５） ；胃肠道反应和骨髓抑制Ｂ 组较Ａ 组增加，Ｃ组较Ａ 组无明显增加。 结论 ＬＦＰ方案价值有待进一步研究，临床上可有选择地应用。ＬＦＨ 方案是治疗晚期结直肠癌有希望的方案。
To study initial responses and toxicities of a series of leucovorin(LV) plus fluorouracil(5 FU) regimens in the treatment of advanced colorectal carcinoma.METHODS Ninety three patients respectively received chemotherapy as follows:①group(LF) A 5 FU(500?mg/m 2·d -1 ) plus LV(20?mg/m 2·d -1 ) was administered iv for 5 d every 3?wk;②group(LFP)B cisplatin(PDD,40?mg/d administered iv for 3d) was added to 5 FU/LV in group A above;③group(LFH)C hydroxyl camptothecin (HCPT,6-8?mg/m 2·d -1 administered iv for 5-10 d) was added to 5 FU/LV in group A above.Each case was assessed after 2 courses of treatment.RESULTS The objective response rates were 12.5%(5/40) in group A,22.2%(6/27) in group B and 34.6%(9/26) in group C.The response rate in group C was more pronounced than that in group A with statistical significance ( P <0 05),but adverse reactions were not markedly increased.CONCLUSIONS LFP regimen value merits further clinical test and is used selectively.LFH regimen seems to be a promising regimen in the treatment of advanced colorectal carcinoma.
出处
《中国癌症杂志》
CAS
CSCD
1999年第3期221-223,共3页
China Oncology
关键词
结肠肿瘤
直肠肿瘤
醛氢叶酸
氟尿嘧啶
Leucovorin Fluorouracil Cisplatin Hydroxyl camptothecin Advanced colorectal carcinoma
