摘要
目的：探讨胰腺癌组织基质质属蛋白酶２（ ＭＭＰ２） 和基质金属蛋白酶抑制剂２（ＴＩＭＰ２） 表达与肿瘤侵袭转移和预后的关系。方法： 通过免疫组化方法检测３５ 例胰腺癌病理标本和１０ 正常胰腺标本ＭＭＰ２ 和ＴＩＭＰ２ 的半定量表达情况及其与肿瘤临床病理参数和预后的关系，生存分析采用Ｋａｐｌａｎｍｅｉｅｒ 方法。结果：胰腺癌ＭＭＰ２ 和ＴＩＭＰ２ 表达阳性率明显高于正常对照组， 与淋巴结转移和临床分级密切相关， 但与胰腺癌的分化程度无关，Ｋａｐｌａｎｍｅｉｅｒ 分析发现ＭＭＰ２ 和ＴＩＭＰ２ 高表达患者的生存时间明显低于ＭＭＰ２ 和ＴＩＭＰ２ 低表达患者（ Ｐ＜０－００１） 。结论：胰腺癌ＭＭＰ２ 和ＴＩＭＰ２ 表达与肿瘤侵袭转移和预后密切相关，有助于确定术后治疗方案。
Objective:To investigate the roles of matrix metalloproteinase 2 (MMP 2) and tissue inhibitor of metalloproteinase 2(TIMP 2) in tumor invasion and metastasis or as a prognostic factor in patients with pancreatic cancer. Methods:Tissues were obtained from 35 patients with pancreatic cancer and 10 patients without pancreatic disease. Expression of MMP 2 and TIMP 2 was examined by immunohistochemical technique and scored semiquantitatively (score 0 3) in carcinoma cells, and the results were correlated with clinicopathological tumor parameters.Survival analyses were done using the Kaplan Meire method. Results:Expression of MMP 2 and TIMP 2 was significantly higher in patients with pancreatic cancer than that in normal persons. Expression of MMP 2 and TIMP 2 was significantly correlated with lymph node metastasis and TNM clinical staging sysfem,and did not correlate with histologic classification.Kaplan Meire analysis revealed an association of increasing MMP 2 and TIMP 2 expression with worse prognosis (P< 0 001). Conclusion:MMP 2 and TIMP 2 are believed to contribute to the invasive properties of pancreatic cancer,which can be used to evaluate the prognosis of patients and may be helpful in designing treatment protocols.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第5期541-544,共4页
Chinese Journal of Cancer
关键词
胰腺肿瘤
肿瘤转移
MMP-2
TIMP-2
Mmatrix metalloproteinase 2
Tissue inhibitor of metalloproteinase 2
Pancreatic cancer
Tumor invasion
Prognosis
Immunohistochemistry
