摘要
目的探讨依那普利联合卡维地洛在老年慢性心力衰竭患者治疗中的疗效、耐受性和安全性。方法选择老年充血性心力衰竭(CHF)患者130例,随机分为常规治疗组(对照组,28例)、依那普利与卡维地洛联合治疗组(观察组,42例)、依那普利治疗组31例和卡维地洛治疗组29例。4组治疗前和治疗6个月后,均使用超声心动图分别测定左心室舒张末期内径(LVEDD)、心输出量(CO)和左心室射血分数(LVEF),进行疗效观察。结果治疗后4组LVEDD较治疗前显著减少(P<0.05),LVEF和CO较治疗前显著增高(P<0.05);治疗后观察组、LVEDD低于对照组(P<0.05),LVEF和CO较对照组显著增高(P<0.05)。结论在常规治疗老年CHF患者的基础上,加用目标剂量的依那普利联合卡维地洛,对CHF患者安全有效,能明显改善心功能,提高左室射血分数。
Objective To investigate the therapeutic effects,tolerance and safety of enalapril and carvedilo in the treatment of congestive heart failure（CHF）in elderly patients.Methods 130 elderly patients with CHF were randomly divided into routine treatment group（control group,n=28）,enalapril plus carvedilo treatment group（observation group,n=42）,enalapril treatment group（n=31）and carvedilo treatment group（n=29）.Left ventricular end diastolic diameter（LVEDD）,cardiac output（CO）and left ventricular ejection fraction（LVEF）were measured before and 6 months after treatment.Results Compared with pre-treatment,LVEDD in four groups decreased significantly while LVEF and CO increased significantly post-treatment（P0.05）.After treatment,LVEDD reduced significantly while LVEF and CO elevated significantly in observation group compared with control group（P0.05）.Conclusion Adding enalapril and carvedilo to basic routine treatment is safe and effective for elderly patients with CHF,which can obviously improve their heart function and increase LVEF.
出处
《西南国防医药》
CAS
2011年第5期493-495,共3页
Medical Journal of National Defending Forces in Southwest China
