摘要
目的探讨胰腺实性假乳头状瘤(SPT)的临床表现、病理学特征及免疫组织化学特点,提高对此病的认识。方法对25例SPT进行临床表现、组织病理、免疫表型的观察并复习相关文献。结果 25例SPT中6例临床表现为上腹部不适,18例为体检偶然发现,1例为外伤后发现,7例发生在胰头,12例发生在胰体尾,6例发生在胰旁。其中7例显微镜下可见坏死、神经血管侵犯等现象。术后随访2-76月,所有患者尚未发现复发及转移。免疫组织化学结果显示肿瘤细胞表达Vimentin(25/25)、Syn(25/25)、AAT(25/25)呈强阳性,CD10(10/25)、CK(6/25)、ER(2/25)、PR(23/25)、CgA(2/25)呈部分阳性,Ki-67阳性表达<3%。结论 SPT是少见的胰腺肿瘤,多见于年轻女性,一般无特异性临床表现,所有病变均发生囊性变,影像学检查有一定特异性。病理特点以温和一致的类圆形或卵圆形细胞增生呈实性结构,并伴出血和囊性变,部分组织退变呈假乳头结构为主要组织学特征。
Objective To analyze the clinicopathological features of solid pseudo-papillary tumor（SPT） of the pancreas.Methods The clinical and pathological data of 25 cases of pancreatic SPT were analyzed and the relevant literatures were reviewed.Immunohistochemical staining for Vimentin,Syn,AAT,CK,ER,PR,CgA,CD10 and Ki-67 on the tissue sections were performed.Results Among 25 cases of SPT,3 were males and 22 females,the age ranged from 12 to 61years with the average of 29.3.Six cases presented clinical symptom with uncomfortable upper abdomen,18 cases were found during routine health checks,1 case was detected after trauma.The lesions were located at the head of pancreas in 7 cases,at the body and tail in 12,aside the pancreas in 6.All cases showed cystic-solid gross appearance;7 cases showed necrosis and invasion to blood vessels and nerves.In histological examination,the tumor cells showed nestlike and pseudo-papillary characters.Immunohistochemical study showed strong staining for Vimentin（25/25）,Syn（25/25）,AAT（25/25）,CK（6/25）,ER（2/25）,PR（23/25）,CgA（2/25） and CD10（10/25）;while the positive staining for Ki-67 was less than 3%.None of them had recurrence or metastasis after 2-76 months of follow-up.Conclusions SPT is a rare pancreatic tumor and prone to occur in young female without special clinical manifestation.Pathological examination showed mild uniform round or oval cells forming solid and papillary structure with hemorrhage and cystic degeneration.
出处
《实用肿瘤杂志》
CAS
北大核心
2011年第2期147-149,共3页
Journal of Practical Oncology
