摘要
目的:探讨内镜下醋酸联合靛胭脂染色对胃黏膜平坦型病变的临床辅助诊断价值。方法:就诊患者行常规内镜检查,有胃黏膜平坦型病变者随机分为2组,染色组行内镜下醋酸联合靛胭脂染色后活检;对照组不染色,肉眼判断病灶,常规活检。结果:共入选240例,染色组和对照组各120例。染色组中18例出现喷洒染色剂后黏膜退色,其早期胃癌、高级别上皮内瘤变发现率之和为94.4%(17/18);79例出现喷洒染色剂后黏膜着色不良,其肠上皮化生、低级别上皮内瘤变的发现率之和为91.1%(72/79)。染色组共检出早期胃癌10例(8.3%)、上皮内瘤变25例(20.8%)、肠上皮化生58例(48.3%);对照组共检出早期胃癌2例(1.7%)、上皮内瘤变6例(5.0%)、肠上皮化生32例(26.7%)。结论:内镜下醋酸联合靛胭脂染色可提高胃平坦型病变患者早期胃癌及癌前病变的发现率,黏膜退色对于早期胃癌和高级别上皮内瘤变、黏膜着色不良对于肠上皮化生和低级别上皮内瘤变的诊断有一定的指示意义。
Objective：To evaluate the clinical value of acetic acid and indigo carmine staining in the auxiliary diagnosis of fiat gas- tric lesion. Methods：After conventional electronic endoscopic diagnosis, the patients with fiat gastriet lesions were randomly divided into 2 groups,staining group was directly sprayed with acetic acid and indigo carmine, then biopsy, the control group was not stained, determined by the naked eye and conventional biopsy. Results：Two hundred and forty patients were adopted, 120 cases of each group. In the staining group, 18 cases had mucosa discoloration, the detection rate of early gastric cancer and high grade in- traepithelial neoplasia was 94.4% （17/18）, 79 cases appeared poorly stained, the detection rate of intestinal metaplasia and low grade intraepithelial neoplasia was 91.1%（72/79）. In the staining group, 10 early gastric cancers, 25 intraepithelial neoplasia and 58 intestinal metaplasia were found, while in the control group 2 early gastric cancers, 6 intraepithelial neoplasia and 32 intestinal metaplasia were found respectively. Conclusion：Staining with acetic acid and indigo carmine improves the detection rates of early gastric cancer and precancerous lesion in fiat gastric lesions, especially in the discoloration and poorly stained areas.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2011年第3期414-418,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省"六大人才高峰"第五批高层次人才资助项目
关键词
醋酸
靛胭脂
胃平坦型病变
acetic acid
indigo carmine
flat gastric lesion
