摘要
目的调查以头孢替安为主的药源性发热情况,促进安全合理用药。方法通过对258例,其中涉及头孢替安125例住院病史的分析,总结头孢替安等药物致发热的情况。结果头孢替安在临床使用频率较高。头孢替安致药源性发热:高度可能6例,肯定8例,共14例。结论药源性发热处理不当,会误导临床治疗;头孢替安的药源性发热情况应在药品说明书中给予警示,以促进安全医疗与合理用药;考虑到头孢替安药效学及药动学不具有优势,不良反应较多,临床应少用为宜。
Objective Investigate the drug-induced hyperthermia due to cefotiam and other antibacterials in order to promote safe and rational medical treatment.Methods Medical records of 258 in-patients,including 125 cases treated with cefotiam were analyzed,drug-induced hyperthermia due to cefotiam and other medication ws summarized.Results Cefotiam is widely used in China.The patiensts of drug-induced hyperthermia due to cefotiam were 6 cases possible,8 cases affirmed,totally 14 cased,and the rate among patients administrated cefotiam was 11.2%.The total rate of drug-induced hyperthermia among all the patients was 7.8%.Conclusion The package insert should suggest the possible hyperthermia induced by cefotiam in order to keep the safe and rational medical treatment.Considering the poor PK and PD,and its adverse drug reactions of cefotiam,cefotiam must be used as less as possible.
出处
《中国药事》
CAS
2011年第4期412-415,共4页
Chinese Pharmaceutical Affairs
