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Androgen deprivation therapy for prostate cancer: not so simple 被引量:2

Androgen deprivation therapy for prostate cancer: not so simple
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摘要 Prostate cancer (PC) is the second most diagnosed visceral malignancy in men worldwide, with over 900 000 new diagnoses each year.1 Approximately 50% of patients treated in industrialized nations will receive androgen deprivation therapy (ADT) at some point in their lifetimes.2 The use of ADT as a treatment approach is likely to increase as new drug developments have focused on intensifying the effect of reducing androgen receptor activation. Prostate cancer (PC) is the second most diagnosed visceral malignancy in men worldwide, with over 900 000 new diagnoses each year.1 Approximately 50% of patients treated in industrialized nations will receive androgen deprivation therapy (ADT) at some point in their lifetimes.2 The use of ADT as a treatment approach is likely to increase as new drug developments have focused on intensifying the effect of reducing androgen receptor activation.
机构地区 Division of Urology
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第2期187-188,共2页 亚洲男性学杂志(英文版)
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  • 1Ferlay J, Shin HR, Bray F, Forman D, Mathers C et al. GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide:IARC CancerBase No. 10 [Internet]. Lyon:International Agency for Research on Cancer; 2010. http://globocan.iarc.fr/factsheets/cancers/prostate.asp.
  • 2Meng MV, Grossfeld GD, Sadetsky N, Mehta SS, Lubeck DP et al. Contemporary patterns of androgen deprivation therapy use for newly diagnosed prostate cancer. Urology 2002; 60:7-11.
  • 3Alibhai SM, Gogov S, Allibhai Z. Long-term side effects of androgen deprivation therapy in men with non- metastatic prostate cancer: a systematic literature review. Crit Rev Oncol Hemato12006; 60: 201-15.
  • 4Alibhai SM, Breunis H, Timilshina N, Marzouk S, Stewart D et al. Impact of androgen-deprivationtherapy on cognitive function in men with nonmetastatic prostate cancer. J Clin Oncol 2010; 28: 5030-7.
  • 5Alibhai SM, Breunis H, Timilshina N, Johnston C, Tomlinson Get al. Impact of androgen-deprivation therapy on physical function and quality of life in men with nonmetastatic prostate cancer, d Clin Onco12010; 28: 5038-45.
  • 6Nelson C J, Lee JS, Gamboa MC, Roth AJ. Cognitive effects of hormone therapy, in men with prostate cancer: a review. Cancer2008; 113: 1097-106.
  • 7Chen Y, Clegg N J, Scher HI. Anti-androgens and androgen-depleting therapies in prostate cancer:new agents for an established target. Lancet Oncol 2009; 10; 981-91.

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