摘要
三十年前,自由基反应在有机合成中的应用已经非常普遍,但其主要集中在碳自由基的应用上,而杂原子自由基却一直得不到发展.氮自由基环化反应是在近十年内才逐步应用到有机合成中的,它对合成一系列的氮杂环化合物有重要的意义,如内酰胺类、吡咯烷类、生物碱类物质等.从四个方面对氮自由基经环化反应合成多种氮杂环化合物的研究进展做一介绍.
Radical reactions were applied widely in organic synthesis about three decades ago, but most of the synthetic applications have concerned on carbon-centered radicals, while heteroatom-centered radicals have received much less scrutiny. The cyclizations of nitrogen radicals in organic synthesis have gained increasing attentions in the past few years, because it is very important for synthesizing N-heterocycle cornpounds, such as lactams, pyrrolidines, alkaloids and so on. This review describes the recent progress of nitrogen radicals on the cyclization to form various N-heterocycles.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2011年第4期453-465,共13页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.20802015
20772115)
高等学校博士学科点专项科研基金(No.20070358018)资助项目
关键词
自由基反应
有机合成
氮自由基
环化反应
氮杂环
radical reaction
organic synthesis
nitrogen radical
cyclization
N-heterocycle
