摘要
目的:探讨溶血磷脂酸(LPA)和氧自由基在脑血栓形成的病理过程中的作用。方法:通过检测90例脑血栓形成患者(CT组)血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、LPA的浓度情况,并与短暂性脑缺血发作(TIA)组(45例)、对照组(45例)比较。结果:血清中SOD的浓度,CT组(治疗前)低于TIA组和对照组(P<0.05),TIA组和对照组无差异(P>0.05);血清中MDA的浓度,CT组(治疗前)高于TIA组和对照组(P<0.01),TIA组和对照组无差异(P>0.05);血清中LPA的浓度,CT组(治疗前)高于TIA组(P<0.01),TIA组高于对照组(P<0.05)。CT组治疗后,疗效显效组血清中SOD浓度明显高于非显效组(P<0.05),显效组血清中MDA浓度明显低于非显效组(P<0.05)。结论:脑血栓形成患者急性期血清中LPA、MDA的浓度显著升高,SOD的浓度显著降低。LPA可能参与促进了脑血栓的形成过程,而氧自由基可能在脑组织缺血再灌注损伤环节加剧了脑血栓形成患者的神经功能损害。
Objective To investigate the role of lysophosphatidic acid（LPA） and oxygen free radical in pathogenesis of patients with cerebral thrombosis.Methods A total of 90 patients with cerebral thrombosis（CT） were selected as the CT group and their serum malonilaldehyde（MDA）,superoxidase dismutase（SOD） and lysophosphatidic acid（LPA） levels were detected.The results were compared with those patients in the TIA（transient ischemic attack） group（45 cases） and control group（45 cases）.Results The serum SOD level in the CT group（before treatment） decreased significantly than that of the TIA and control groups（P0.05）,but the intergroup difference between the TIA and control groups had no significance（P0.05）.While the serum MDA level in the CT group（before treatment） was higher than that of the TIA and control groups（P0.01）,with no difference between the latter two groups（P0.05）.The serum LPA level in the CT group（before treatment） increased significantly than that of the TIA group（P0.01）,and the latter one was higher than that of the control group（P0.05）.After treatment,the SOD level became higher（P0.05）,while MDA level decreased profoundly（P0.05） in effective group than that in the noneffective group.Conclusion The serum LPA,MDA levels increase but SOD decreases significantly in patients with cerebral thrombosis at acute phase.LPA might take part in accelerating cerebral thrombosis,while oxygen free radical might aggravate the neurological dysfunction in ischemia-reperfusion injury of brain.
出处
《放射免疫学杂志》
CAS
2011年第2期171-173,共3页
Journal of Radioimmanology
