摘要
目的:通过分析非手术胸段食管鳞癌患者转移淋巴结体积(VLN)与生存的关系,探讨其对非手术食管癌患者预后的影响。方法:回顾性分析接受根治性放化疗的70例有淋巴结转移的胸段食管癌患者的临床及随访资料。按淋巴结体积分为A组25例、B组23例和C组22例,比较3组患者生存率的差异,分析转移淋巴结体积对非手术胸段食管鳞癌患者预后的影响。结果:中位随访26个月,70例患者1、2和3年总生存率分别为60.5%、44.3%和13.0%。A、B和C组的中位生存时间分别为(31±2.566)(、21±2.057)和(10±0.739)个月,组间比较差异均有统计学意义,P均<0.05;A、B和C组的1、2和3年生存率差异均具有统计学意义,P值均<0.05;Cox回归显示,转移淋巴结体积及T分期是影响非手术胸段食管鳞癌患者生存的独立因素。结论:转移淋巴结体积是影响非手术胸段食管癌患者预后的一个重要因素,对淋巴结体积与非手术食管癌预后关系的深入研究可能有助于指导非手术食管癌的分层治疗。
OBJECTIVE：To investigate the effect of metastatic lymph node volume（VLN） on the prognosis of patients with thoracic esophageal squamous cell carcinoma（TESCC） by analyzing the relationship between VLN and survival data of TESCC.METHODS：The data from 70 cases of TESCC with lymph node metastases treated was divided into A（n=25）,B（n=23） and C（n=22） groups,and analyzed by radiochemotherapy.The survival difference and the impact of various VLN groups on survival were compared.RESULTS：With a median follow-up of 26 months,the overall survival rates at 1,2 and 3 years were 60.5%,44.3% and 13.0%,respectively.The values of median survival time of the three VLN groups were（31±2.566）,（21±2.057） and（10±0.739）months（P0.05）,The 1-,2-,3-year survival rates of the three VLN groups were significantly from each other（P0.05）.The VLN and T staging were the most important prognostic factors.CONCLUSIONS：The metastatic LN volume is an important prognostic factor in non-operable TESCC.The further exploration is warranted so as to direct the stratified-treatment of TESCC.
出处
《中华肿瘤防治杂志》
CAS
2010年第22期1845-1848,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
食管肿瘤
淋巴结体积
生存分析
预后
esophageal neoplasms
volume of lymph node
survival analysis
prognosis
