摘要
目的:观察吉西他滨联合奥沙利铂(L-OHP)、左旋门冬酰胺酶(L-ASP)对复发性或难治性进展型非霍奇金淋巴瘤的疗效和不良反应。方法:吉西他滨1000mg/m2,d1,d8,静脉滴注;L-OHP 80mg/m2,d1,d8,静脉滴注;L-ASP 1000 u/d,d1-d8静脉滴注。3-4周为一个化疗周期。20例复发性或难治性进展型非霍奇金淋巴瘤患者,疗程不少于3个周期。结果:20例患者中,14例获得缓解,占77.8%。其中完全缓解(CR)6例,部分缓解(PR)8例。6例具有B类症状的患者中,4例症状消失,1例明显改善,1例无改善。化疗不良作用主要为轻度的胃肠道反应,极少数患者出现严重的骨髓抑制。结论:吉西他滨联合L-OHP、L-ASP对复发性或难治性进展型非霍奇金淋巴瘤有较好的近期疗效,能明显改善患者症状,且大部分患者可以承受其不良反应,是一个值得进一步验证的补救性化疗方案。
Objective：To evaluate the efficacy and drug-related toxicity of combined gemcitabine,oxaliplatin,and L-asparaginase for the treatment of patients with relapsed or refractory aggressive non-Hodgkin′s lymphoma（NHL）.Methods： Twenty patients with histologically confirmed relapsed or refractory aggressive NHL were included in this study.Gemcitabine was given on d1,8 of a three to four weeks schedule at a dose of 1 000 mg/m2 intravenously over 30 minutes for no less than three cycles,and oxaliplatin was given on d1,3 at a dose of 80mg/m2.L-asparaginase was taken orally on d1-8 at a dose of 1000 u/d.Results： Of 20 patients,11 patients（73.3%） showed responses：5 patients（33.3%） complete response and 6 patients（40.0%） partial response.Four patients′ symptoms disappeared,and 1 in 6 patients was alleviated of type B symptoms.Drug-related toxic effects of chemotherapy were mild gastrointestinal reactions in most patients and severe bone marrow depression in very few patients.Conclusion： The present combination of gemcitabine,oxaliplatin,L-asparaginase possesses moderate short-term efficacy,acceptable toxicity,and alleviation of suffering related to the disease.This protocol is worthy to be warranted as salvage for relapsed or refractory aggressive NHL.
出处
《现代肿瘤医学》
CAS
2011年第3期548-550,共3页
Journal of Modern Oncology
