摘要
目的总结乳腺癌间质成纤维母细胞的生物学特性及研究现状。方法分析近年来有关乳腺癌间质成纤维母细胞研究的相关文献。结果乳腺癌组织的构成除肿瘤细胞本身外,尚包括间质成分,而成纤维母细胞是乳腺癌间质的主要成分。乳腺癌间质中成纤维母细胞与正常乳腺组织中成纤维细胞除产生胶原物质外,它们的生物学特性存在明显差异,前者表现为-αSMA阳性、p53基因突变,同时能够分泌多种细胞因子/趋化因子,通过多种信号通路参与乳腺癌细胞的生长、迁移、浸润及转移。结论乳腺癌间质成纤维母细胞的生物学特性可反映病变性质,对乳腺癌的诊断和鉴别诊断以及预后预测有着重要的意义。针对乳腺癌间质成纤维母细胞的靶点治疗正在受到更多的关注。
Objective To summarize the research status and biological characteristics of stromal fibroblast in breast cancer.Methods Relevant literatures about the breast cancer stromal fibroblasts published recently were collected and reviewed.Results In addition to cancer cells,breast cancer included stromal cells.The fibroblasts were the major components of breast cancer stromal,which had significantly different biological characteristics from normal fibroblasts.The fibroblasts were characterized by α-SMA positive,p53 gene mutation,secretion of various cytokines or chemokines in addition to the production of collagen substances,involving in breast cancer growth,migration,invasion and metastasis through a variety of signaling pathways.Conclusion The biological characteristics of stromal fibroblasts in breast cancer may reflect lesion properties,be of great importance to diagnosis and differential diagnosis and prognosis prediction of breast cancer.More attentions will be paid to the target therapy for stromal fibroblasts in breast cancer.
出处
《中国普外基础与临床杂志》
CAS
2011年第2期212-215,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金资助项目(项目编号:30872516)~~
关键词
乳腺癌
间质
成纤维母细胞
生物学特性
研究现状
Breast cancer
Stroma
Fibroblasts
Biological characteristics
Research status
