摘要
目的研究银桔颗粒的抗炎作用及作用机制。方法对鸡蛋清致大鼠足跖炎性组织中超氧化物歧化酶（SOD）活力测定，进行体外抑菌实验考察银桔颗粒的抗炎抑菌作用，并观察小鼠腹腔内巨噬细胞对红细胞的吞噬功能。结果与对照组比较，大、中、小剂量组大鼠足跖炎性组织中SOD含量差异均有统计学意义（均P〈0．01），小鼠腹腔巨噬细胞对红细胞的吞噬百分率及吞噬指数均显著增高（均P〈0．01）。银桔颗粒粒对4种致病菌的最低抑菌和最小杀菌浓度（MBC）分别为：肺炎链球菌（MIC0．286g/ml，MBC0．429g／ml）；克雷伯菌（MIC0．140g／ml，MBC0．275g／ml）；铜绿假单胞菌（MIC0．0177g／ml），MBC0．0358g／ml）；大肠杆菌（MIC0．429g／ml，MBC0．429g／ml）。结论银桔颗粒具有良好的抗炎抑菌增加免疫力作用。
Objective To investigate the anti-inflammatory effect and mechanism of Yijie particles. Methods Took the energnmetry of SOD in foot of rats metatarsal inflammatory organization induced by egg white, Maked antibacterial experiment investigation in vitro to observe the anti-inflammatory effect of Yijie particles and observed mice abdominal maerophage phagocytosis function of red blood cells. Results Compared to the control group, the SOD of content in the large,medium and small dose group were statistically significant difference （ all P 〈 0.01 ）, the mice abdominal maerophage phagocytosis percentage of red blood cells and devour exponential increased significantly（ all P 〈 0.01 ）. 4 kinds of pathogenic bacteria of the lowest antibacterial and minimum bactericidal concentration （ MBC ）, respectively, streptococcus pneumoniae （ MIC 0.286g/ml, MBC 0.429g/ml） ; Clay white fungus （ MIC 0.140g/ml ,MBC 0. 275g/ml） ; Pseudomonas aeruginosa （ MIC 0. 0177g/ml ） , MBC 0. 0358g/ml ） ; E. coli（ MIC 0. 429g/ml, MBC 0. 429g/ml ）. Conclusion Yijie particles had remarkable anti-inflammatory and better antibacterial effect.
出处
《中国基层医药》
CAS
2011年第4期495-497,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
银桔颗粒
抗炎
超氧化物歧化酶
抑菌
Yijie particles
Anti-inflammatory
SOD ： Antibacterial effects
