摘要
目的比较术后应用地佐辛与苏芬太尼进行患者静脉自控镇痛（PCIA）的临床效果和安全性。方法60例择期全麻下胸腹部及盆腔手术患者，ASAⅠ-Ⅲ级，随机分为地佐辛组（A组）和苏芬太尼组（B组），每组30例。镇痛泵药物配方：A组为地佐辛0．6mg／kg＋恩丹西酮8mg＋0．9％氯化钠注射液至100ml；B组为苏芬太尼2．5μg／kg＋恩丹西酮8mg＋0．9％氯化钠注射液至100ml；首次剂量A组为地佐辛0．1mg／kg＋恩丹西酮4mg，B组为苏芬太尼0．1μg/kg＋恩丹西酮4mg；镇痛泵注射速度为2ml／h，自控剂量为1ml，锁定时间为15min。观察并记录患者的生命体征（BP、HR、SPO2）及1h、2h、4h、12h、24h、48h疼痛评分（VAS）、镇静评分（Ramsay）、舒适度评分（BCS）及不良反应。结果所有患者的生命体征均平稳；A、B两组的Ramsay、VAS、BCS评分在各时间点间差异均无统计学意义（均P〉0．05）。两组不良反应发生率差异无统计学意义（P〉0．05）。结论地佐辛用于术后静脉镇痛可以取得和舒芬太尼一样的满意效果。
Objective To evaluate the effect and safety of dezocine and sufentanil in intravenous analgesia for postoperative pain. Methods 60 patients with ASA Ⅰ-Ⅲ,underwent general anaesthesia operation were divided into two groups randomly, with 30 cases for each group：dezocine 0.6mg/kg and sufentanil 0.6mg/kg was applied to PCIA in group A and B. PCIA was administered with subsequent bolus of lml with lockout time 15 minutes and background infusion of 2ml/h. The analgesic effect was evaluated by VAS, BCS and Ramsay at 1,2,4,12,24,48 hours after operation. The changes of vital sign were also assessed. Results There was no significant difference between two groups in analgesia effect （ all P 〉 0.05 ） and adverse reaction incidence rate （ P 〉 0.05 ）. Conclusion The effect of dezocine in intravenous analgesia for postoperative pain could be as satisfaction as that of sufentainyl.
出处
《中国基层医药》
CAS
2011年第4期485-487,共3页
Chinese Journal of Primary Medicine and Pharmacy
