摘要
目的观察不同他汀类药物对动脉粥样硬化疗效的比较研究。方法 240例动脉粥样硬化患者随机分为A、B、C、D4组,每组60例,A组采用阿托伐他汀治疗,B组采用辛伐他汀治疗,C组采用氟伐他汀治疗,D组给予饮食控制。服药前和服药6个月末,比较TC、TG、HDL-C、LDL-C、血浆高敏C反应蛋白(hs-CRP)、颈动脉斑块面积及内膜中层厚度(IMT)的变化。结果治疗6个月后A、B、C 3组TC、TG、HDL-C、LDL-C、hs-CRP水平、颈动脉斑块面积及IMT与治疗前相比差异均有统计学意义(P<0.05),但D组与治疗前比较差异无统计学意义(P>0.05)。结论他汀类药物对动脉粥样硬化斑块具有较好的疗效,不同种类的他汀类药物疗效没有明显差异。
Objective To observe the curative effects of different statins on atherosclerotic.Methods 240 cases of atherosclerosis patients were randomly divided into A,B,C,D groups and each group had 60 patients.Group A taken atorvastatin,group B taken simvastatin,group C taken fluvastatin,group D gave diet control.The levels of TC,TG,DHL-C,LDL-C,hs-CRP,and the area of plaques and IMT were compared between before and after of administration.Results After 6 months of administration,the levels of TC,TG,HDL-C,LDL-C,hs-CRP,and the area of plaques and IMT had significant changes compared with before administration,in A,B and C groups（P0.05）,But D group had no significant changes compared with before administration（P0.05）.Conclusion Statins has good curative effect on atherosclerotic plaque,therapy efficacy of different kinds of statin have no obvious difference.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第6期587-589,共3页
Chongqing medicine
