摘要
目的了解该地区泌尿生殖道支原体的感染情况和对10种抗生素的药物敏感性,为临床合理治疗提供依据。方法采用板条培养药敏试剂法,对637例泌尿生殖道患者进行解脲支原体和人型支原体培养及药敏实验,并对阳性标本进行抗生素的药敏检测。结果 637例受检标本中有317例呈阳性,阳性率为49.8%;其中男、女性标本的阳性率分别为39.4%、52.7%,女性感染率显著高于男性(χ2=77.9,P<0.01)。解脲支原体、人型支原体以及解脲支原体合并人型支原体感染的阳性率分别为33.3%、0.9%和15.5%。药敏结果显示,支原体对交沙霉素、强力霉素和美满霉素3种抗生素较为敏感,其敏感性都在83.3%以上;解脲支原体及解脲支原体合并人型支原体标本对环丙沙星的耐药性最高,其耐药率都在74.1%以上;而人型支原体对罗红霉素和阿奇霉素的耐药性最高,其耐药率均为83.3%。在317例阳性标本中有47.9%的标本呈多重耐药现象。结论该地区支原体阳性感染率较高,主要以解脲支原体为主,人型支原体及解脲支原体合并人型支原体的感染也不容忽视。支原体对常规的抗生素已产生一定的耐药性,临床应根据药敏实验结果合理使用抗生素,如不能作药敏实验,可以用交沙霉素、强力霉素和美满霉素作为治疗支原体感染的首选药物。
Objective To know about the urogenital tract infections caused by Mycoplasma in Shenzhen and the sensitivities to the 10 antimicrobials in vitro, to provide guidance for rational clinical treatment. Methods Ureaplasma urealyticum（Uu） and Myco- plasma hominis（Mh） were detected with lath culture sensitivity reagent method for 637 patients with urogenital tract infection and drug susceptibility test results were analyzed for antibiotics. Results Among the 637 samples,317 were positive（49. 8%） ,Among 142 males, 56 were positive （ 39.4 % ）. Among 495 females, 261 were positive （52.7 % ）. Females were more apt to be infected （ X2 = 77.9, P〈0. 01）. The positive rate of Uu infection, Mh infection, both Uu and Mh infection was 33.3%, 0.9 %, 15.5 %, respectively. The results of drug sensitivity showed that over 83.3 % of Mycoplasma were sensitive to josamycin,minocyclin and doxcycline. Ciprofloxacin got the highest drug resistance rate in Uu and both Uu and Mh, all higher than 74.1%. Both roxithromycin and az- itromucin had the highest drug resistance in Mh（83. 3 %）. The rate of 47. 9% among 317 positive samples had multi-resistance. Conclusion The infection rate of Mycoplasma in the patient with urogenital tract infection in Shenzhen is high,especially the infection of Uu is usual. Mh, both Uu and Mh in the patient are in a rising tendency. The clinical doctor should rationally choose and use antibiotics according to the drug susceptibility. If drug sensitivity tests is failed to be done,josamycin, doxcycline and minocyclin should be choosed as the main drugs.
出处
《国际检验医学杂志》
CAS
2011年第1期29-30,32,共3页
International Journal of Laboratory Medicine
