摘要
重症手足口病已成为威胁我国儿童健康的重要传染性疾病。目前的观点认为重症手足口病与肠道病毒（EV）尤其是EV71病毒的嗜神经特性有关，危重病例均有脑炎、脑干脑炎或脑脊髓炎症状，并由此导致神经源性肺水肿或循环衰竭，其中交感副交感神经功能失衡、儿茶酚胺大量释放是主要致病机制。危重症治疗需要闯“三关”，即呼吸衰竭（肺水肿）、循环衰竭及脑功能障碍或衰竭。及时的机械通气、恰当的循环功能支持及脑功能保护是降低病死率的关键，应结合患儿实际情况合理应用指南。
Severe hand,foot and mouth disease has emerged as the important threat to lives of children in China in recent years. Enterovirus especially EV 71 is neurotropic pathogen, can cause encephalitis, brainstem encephalitis, which are considered to be related to some severe complications such as Pulmonary edema and cardiovascular failure. Autonomic nervous system dysregulation and secondary excessive catecholamine release are thought to be the main mechanism. The key measures for decreasing mortality include optimal ventilatory and cardiovascular support as well as prevention of further brain injuries. The guideline should be used with cautions and clinical practice should be based on patient＇s conditions.
出处
《中国小儿急救医学》
CAS
2011年第1期4-7,共4页
Chinese Pediatric Emergency Medicine
关键词
手足口病
脑炎
神经源性肺水肿
循环衰竭
儿茶酚胺
Hand,foot and mouth disease
Encephalitis
Neurogenic pulmonary edema
Cardiovascular failure
Catecholamine
