期刊文献+

参芪强心口服液对心力衰竭大鼠心肌细胞凋亡、Bcl-2蛋白表达的影响 被引量:2

在线阅读 下载PDF
导出
摘要 目的观察参芪强心口服液对心力衰竭大鼠心肌细胞凋亡及Bcl-2蛋白表达的影响。方法采用腹主动脉缩窄法构建大鼠慢性心力衰竭模型,术后4 w后开始给药,给药后1月结束试验,观察药物对心肌细胞凋亡及Bcl-2蛋白表达的影响。结果参芪强心口服液能促进Bcl-2蛋白表达,明显抑制心肌细胞凋亡。结论参芪强心口服液可能通过促进Bcl-2基因蛋白表达、减轻心肌细胞凋亡、逆转心脏重构的发生、发展,改善心功能。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第3期482-484,共3页 Chinese Journal of Gerontology
  • 相关文献

参考文献6

二级参考文献10

  • 1Kawai H, Mohan A, Hagen J, et al. Alterations in Cardiac Adrenergic Terminal Function and Beta-adrenoceptor Density in Pacing-induced Heart Failure. Am J Physiol Heart Circ Physiol,2000,278(5) : 1-11708.
  • 2Nagatsu M D, Spinale Ph D, Koide M D, et al. Bradycardia and the Role of β-Blocade in the Amelioration of Left Ventricular Dysfuction. Circulation, 2000,15:653.
  • 3Cihak R, Kolar F, Pelouch V, et al. Functional Changes in the Right and Left Ventricle During Development of Cardiac Hypertrophy and After its Regression. Cardiovasc Res, 1992,26 ( 9 ) :845.
  • 4White M, Yannowitz F, Gilbert E M, et al. Role of Adrenergic Receptor Downregulation in the Peak Exercise in Patients with Heart Failure Due to Idiopathic Dilated Cardiomyopathy. Am J Cardiol, 1995,76 : 1271.
  • 5Anderson F L, Port J D, Reid B B, et al. Effect of Therapeutic Dopamine Administration on Myocardial Catecholamine and Neuropeptide Y Concentrations in the Failing Ventricles of Patients with Idiopathic Dilated Cardiomyopathy. J Cardiovasc Pharmacol,1992,20(5) :800.
  • 6Iaccarno M D, Tomhave B S, Lefkowitz M D, et al. Reciprocal in Vivo Regulation of Myocardial G Protein-Coupled Receptor Kinase Expression by β-Adrenergie Receptor Stimulation and Blockade. Circulation, 1998,98(17) : 1783.
  • 7Colucci W S. The Effects of Norepinephrine on Myocardial Biology: Implications for the Therapy of Heart Failure. Clin Cardiol,1998,21(12 Suppl 1) :120.
  • 8Bhargava V, Shabetai R, Mathiasen R A, et al. Loss of Adrenergic Control of the Force-frequency Relation in Heart Failure Seeondary to Idiopathic or Ischemic Cardiomyopathy. Am J Cardiol,1998,82(8) : 1000.
  • 9王瑜,汪红仪,袁肇侃,赵晓宁,王金晞,张祖暄.槲皮素降低大鼠心率和心肌钙振荡频率和抑制小鼠心肌肥厚(英文)[J].中国药理学报,1999,20(5):426-430. 被引量:3
  • 10胡宇驰,侯家玉.知母合黄芪改善肾性高血压大鼠心功能的研究[J].中国中药杂志,2002,27(11):858-861. 被引量:14

共引文献43

同被引文献40

引证文献2

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部