期刊文献+

Th17细胞在放射性肺损伤中的作用 被引量:1

The Role of Th17 Cells in Radiation-induced Lung Injury
原文传递
导出
摘要 放射性肺损伤是胸部恶性肿瘤放疗、骨髓移植预处理后常见并发症,T淋巴细胞介导的免疫反应在放射性肺损伤的发病机制中扮演了重要角色。研究已证实TGF-β、IL-17、IL-6及TNF-α不仅是调控Th17细胞发育分化的关键因子,而且在放射性肺炎和肺纤维化的发病机制中具有关键作用。Th17细胞很可能参与了放射性肺损伤的发病机制。
作者 钱莘
出处 《肿瘤学杂志》 CAS 2010年第12期914-917,共4页 Journal of Chinese Oncology
  • 相关文献

参考文献20

  • 1Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and im- plications for future research [J]. Int J Radiat Oncol Biol Phys, 2006, 66(5): 1281-1293.
  • 2Roberts CM, Foulcher E, Zaunders JJ, et al. Radiation pneumonitis: a possible lymphocyte-mediated hyper-sensi- tivity reaction[J]. Ann Intern Med, 1993, 118(9):696-700.
  • 3Rtibe CE, Wilfert F, Palm J, et al. Irradiation induced a biphasic expression of pro-inflammatory cytokines in the lung[J]. Strahlenther Onkol, 2004, 180(7): 442-448.
  • 4Luzina IG, Todd NW, Iacono AT, et al. Roles of T lym- phocytes in pulmonary fibrosis[J]. J Leukoc Biol, 2008, 83 (2): 237-244.
  • 5Atamas SP, White B. Cytokine regulation of pulmonary fi- brosis in scleroderma [J]. Cytokine Growth Factor Rev, 2003, 14(6):537-550.
  • 6Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy[J]. Curr Opin Immunol, 2007, 19(6):652-657.
  • 7Pene J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infi-ltrated by highly differentiated Th17 lymphocytes[J]. J Immunol, 2008, 180(11): 7423-7430,.
  • 8Ivanov II, McKenzie BS, Zhou L, et al. The orphan nucle- ar receptor RORgammat directs the differentiation program of proinflammatory IL-17^+ T helper cells [J]. Cell, 2006, 126(6): 1121-1133.
  • 9Korn T, Bettelli E, GaoW, et al. IL-21 initiates an alter- native pathway to induce proinflammatory T(H) 17 cells[J]. Nature, 2007, 448(7152): 484-487.
  • 10Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing inter- leukin 17[J]. Nat Immunol, 2005, 6(11): 1133-1141.

同被引文献9

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部