摘要
采用电化学免疫发光法研究癌胚抗原（CEA）异常升高在炎症、肿瘤等不同疾病患者中所占的比例,为临床良恶性疾病的鉴别提供辅助指标。回顾分析我院2010年1月至5月CEA异常升高（大于5μg/L）的住院患者共557例,采用SPSS16.0软件对其进行统计学分析。结果表明,在CEA异常升高的557个病例中,恶性肿瘤占77.74%,良性疾病占22.26%,两组CEA值升高有统计学差异（P〈0.01）;在5.01~10.00μg/L各个范围内,良恶性疾病CEA浓度都没有显著性差异（P〉0.05）;在各癌症组,胃癌,肺癌,结直肠癌组与肝癌组相比有显著差异（P〈0.01）;乳腺癌与肝癌相比有显著差异（P〈0.05）。结论：CEA并非恶性肿瘤的特异性指标,它在良性疾病中的升高也占有一定比例,并集中在5.01~10.00μg/L范围内;CEA大于10.00μg/L时对恶性肿瘤的诊断意义较大。
To investigate the proportion of increasing carcinoma-embryonic antigen（CEA）in patients with malignant and benign diseases,in order to explore its auxiliary diagnosis in clinic,the data of 557 increasing CEA patients in hospital from January to May in 2010 were analyzed retrospectively with SPSS.The results showed that the patients with tumor were 77.74% and the non-tumor patients were 22.26% in all 557 increasing CEA samples.The values of CEA increased had significantly statistics difference between two groups（P0.01）.In the CEA concentration range of 5.01~10.00μg/L,there is no significant difference between malignant and benign diseases groups（P0.05）.The patients with hepatic carcinoma was different significantly from the patients with gastric cancer,lung cancer and colorectal cancer groups respectively（P0.01）.The patients with breast cancer was also different from that of patients with hepatic carcinoma group（P0.05）.The CEA was not a specific tumor marks.It could be also increased in non tumor patients in the CEA concentration range of 5.01~10.00μg/L.When the CEA might concentration is more than 10.00μg/L,it might be more useful in the diagnosis of malignant and benign diseases.
出处
《标记免疫分析与临床》
CAS
2011年第1期1-4,共4页
Labeled Immunoassays and Clinical Medicine
基金
国家科技部重大专项(2008AA022602)
关键词
癌胚抗原
良性疾病
肿瘤
辅助诊断
Carcinoma-embryonic antigen
Benign diseases
Tumor
Auxiliary diagnosis
