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宫颈癌组织中CD146和MMP-14表达的意义及相关性分析 被引量：3

The Expression and Correlation of CD146,MMP-14 in Cervical Squamous Carcinoma
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摘要 目的探讨CD146标记的微血管密度(MVD)和基质金属蛋白酶(MMP-14)在宫颈鳞癌组织中的表达及与其临床病理因素的相关性。方法应用免疫组织化学染色(SP法),检测CD146和MMP-14在82例宫颈鳞癌、48例宫颈上皮内瘤变(CIN)及24例慢性宫颈炎组织中的表达,并对CD146标记的MVD进行图像分析计数。结果宫颈鳞癌组中MMP-14表达及CD146标记的MVD值明显高于CIN组及慢性宫颈炎组(P<0.01)。CD146标记的MVD值及MMP-14表达与肿瘤组织学类型、浸润深度、FIGO分期及淋巴结转移呈正相关(P<0.01),而与患者年龄无关(P>0.05)。CD146表达与MMP-14表达呈正相关(P<0.01)。结论 CD146和MMP-14是宫颈鳞癌发生、浸润及转移的促进因子,CD146表达与宫颈鳞癌组织中MMP-14的异常表达密切相关。 Objective To study the expression of microvessel density（MVD） marked by CD146 and MMP-14 in cervical squamous carcinoma,then to investigate the relationship between MVD,MMP-14 and clinicopathological factors.Methods The expression of CD146,MMP-14 in 82 cases of cervical squamous carcinoma,48 cases of CIN and 24 cases of chronic cervicitis were investigated by immunohistochemical SP method,and MVD marked by CD146 were examined by computer.Results The average MVD marked by CD146 and expression of MMP-14 in cervical squamous carcinoma were significantly higher than that in CIN and cervicitis（P0.01）.They were positively associated with tissue type,depth of invasion,FIGO stage and lymphonode metastasis（P0.01）,and were not associated with age（P0.05）.There was positive correlation between expression of CD146 and MMP-14（P0.01）.Conclusion CD146,MMP-14 are positive regulatory factors of growth,invasion and metastasis of cervical squamous carcinoma.The expression of CD146 is significantly correlated with expression of MMP-14 in cervical squamous carcinoma.
作者 朱燕 杨其昌 刘宏斌 刘曼华 张晓娟 沈屹
机构地区 江苏省南通市第一人民医院
出处 《实用癌症杂志》 2011年第1期16-19,共4页 The Practical Journal of Cancer
关键词 CD146基因 MMP-14基因 宫颈鳞癌 宫颈上皮内瘤变 CD146 gene MMP-14 gene Cervical squamous carcinoma Cervical intraepithelial neoplasia（CIN）
分类号 R737.33 [医药卫生—肿瘤]
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参考文献14

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共引文献18

同被引文献22

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实用癌症杂志
2011年 第1期

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