摘要
选用甲壳糖为原材料，在其主链上引入－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两种基团制备成类肝素化合物研究反应过程中羧甲基和磺酸基取代度的影响因素及不同取代位置、不同取代度的化合物复钙时间和溶血率结果表明，甲壳糖类肝素化合物的抗凝血性能是由甲壳糖主链上引入的－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两种基团的协同效应产生的，血液相溶性的优劣主要取决于－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两者的比例 Ｎ－ Ｃ Ｍ， Ｏ－ Ｓ Ｏ３ Ｈ 甲壳糖，当 Ｎ－ 羧甲基取代度为０５８５ ， Ｏ－ 磺酸基取代度为０５９３ 时其抗凝血性能最优，而 Ｎ－ Ｓ Ｏ３ Ｈ， Ｏ－ Ｃ Ｍ 甲壳糖，当 Ｎ－ 磺酸基取代度为０６８９ ， Ｏ－ 羟甲基取代度为０５９３ 时。
Heparin-like compounds were prepared by introducing-COOH and-SO 3H into chitosan. Influence factors for the degree of substitution of -COOH and -SO 3H in the course of reaction were discussed. Comparasions of recalciffication times and degree of hemolysis of these compounds, with reference to the position and degree of subtitution of each individual group. Results showed that anticogulant properties of heparin-like compounds of chitosan were simultaneously affected by both-COOH and-SO 3H in the main chains of chitosan. N-CM, O-SO 3H chitosan had good anticogulant property when the degree of substitution of N-carboxymethy was 0 585 and that of O-sulfated group was 0 417; N-SO 3H, O-CM chitosan had good blood compatibility when the degree of substitution of N-sulfated group was 0 689 and that of O-carboxymethy was 0 593.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1999年第5期78-83,共6页
Journal of Jinan University(Natural Science & Medicine Edition)
关键词
甲壳糖
类肝素化合物
血液相溶性
抗凝血性
chitosan
heparin-like compound
degree of substitution
blood compatibility
