摘要
目的:对黄根中的蒽醌苷类化合物及其细胞毒活性进行研究。方法:采用大孔吸附树脂柱、硅胶柱、凝胶柱及反相柱色谱法分离单体化合物,根据波谱技术鉴定结构,采用MTT法进行细胞毒活性测定。结果:从黄根乙醇提取物的正丁醇部分离得到6个蒽醌苷类化合物,1-O-methylrubiadin 3-O-β-primeveroside(1),damnacanthol 3-O-β-primeveroside(2),rubiadin3-O-β-primerveroside (3),lucidin 3-O-β-primeveroside(4),1,3-dihydroxy-2-(methoxymethyl) anthraquinone 3-O-β-primerveroside (5)and digiferruginol ω-gentiobiose(6)。结论:化合物16均为首次从该植物中分离得到,蒽醌成苷后生物活性减弱。
AIM：To study the anthraquinone glycosides and their cytotoxicity from the roots of Prismatomeris connata.METHODS：The chemical constituents were isolated by Diaion HP-20 resin,silica gel,Sephadex LH-20 and ODS column chromatography and the structures were elucidated on the basis of spectral analysis.The cytotoxic activity was evaluated by MTT method.RESULTS：Six known anthraquinone glycosides were obtained and their structures were identified as 1-O-methylrubiadin 3-O-β-primeveroside （1）,damnacanthol 3-O-β-primeveroside （2）,rubiadin 3-O-β-primerveroside （3）,lucidin 3-O-β-primeveroside （4）,1,3-dihydroxy-2-（methoxymethyl）anthraquinone 3-O-β-primerveroside （5）,and digiferruginol ω-gentiobiose （6）.CONCLUSION：All the compounds were isolated from this genus for the first time.
出处
《中国天然药物》
SCIE
CAS
CSCD
北大核心
2011年第1期42-45,共4页
基金
深圳市城市管理局科技项目(陈涛2006)资助~~
关键词
黄根
蒽醌苷
细胞毒活性
Prismatomeris connata
Anthraquinone glycosides
Cytotoxic activity
