摘要
目的:考察老鹳草鞣质结肠定位制剂的体外释放特征。方法:以果胶钙为载体材料,老鹳草鞣质为模型药物制备小丸,并将其填充于肠溶胶囊;以没食子酸为检测指标,测定制剂在不同介质中的体外释放度。结果:在人工胃液及人工肠液中5 h累积释放率<10%,在含0.5%果胶酶的人工结肠液中4 h累积释放率>80%。结论:该制剂初步具备结肠定位释药特征。
Objective：To investigate the release properties of geranium tannins colon-specific preparation in vitro. Method： The pellets were prepared by using calcium pectinate as a carrier, Geranium tannins as the model drug to fill in the intestines dissolving capsule. The release of the preparation in different mediums in vitro was determined with gallic acid as the index. Result： The accumulated percentage of release rate of pellets in simulated gastrointestinal fluid was less than 10%, but in the simulated colonic fluid which contained 0. 5% pectin enzyme, the accumulated percentage of release rate reached 80% within 4 hours. Conclusion. The preparation had the characteristics as a colon-specific delivery system.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第3期4-6,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
吉林省科技发展计划项目(2003-0551-8)
吉林省教育厅资助项目(2005-105)
关键词
果胶钙
结肠定位
复合型
calcium pectinatc
colon-specific
compound
