摘要
男性生育力受到许多因素的影响,其中精子DNA损伤一直是生殖医学领域研究的热点之一。精子线粒体、核DNA损伤会导致受精失败或影响受精后原核的形成、胚胎着床及子代的健康。目前,定量检测精子中异常DNA数量的方法有多种,虽然尚不理想,但各有其临床应用价值。精子DNA损伤分析比传统精液常规分析参数更稳定、更敏感。胞浆内单精子注射(ICSI)前先对精子DNA进行评估十分必要。精子DNA损伤程度是新的评价精液质量和预测生育能力的指标。
The male fertility is affected by many factors and sperm DNA damage is one of the hot spots in ART.Spermatozoa mitochondria and nucleus DNA damage have negative effects on normal fertilized process,pronucleus shaping,implantation and offspring health.At present,sperm DNA damage can be detected by more and more methods,although none of these provides an ideal method to assess sperm DNA integrity,and each has its clinical application,which are more stable and more sensitive than the conventional analysis of semen.It is necessary to assess sperm DNA damage before ICSI.Assessment of sperm DNA damage is considered to be a new evaluation of semen quality and fertility prediction indicators.This article reviews the studies on detection of sperm DNA damage and association with reproductive outcomes.
出处
《国际生殖健康／计划生育杂志》
CAS
2011年第1期61-64,共4页
Journal of International Reproductive Health/Family Planning
关键词
不育
男(雄)性
精子
DNA
线粒体
精液
生殖技术
辅助
妊娠结局
INFERTILITY
MALE
Spermatozoa
DNA
mitochondrial
Semen
Reproductive techniques
assisted
Pregnancy outcome
