摘要
目的探讨血清α-L-岩藻糖苷酶(AFU)、5′-核苷酸酶(5′NT)和γ-谷氨酰转肽酶(γ-GGT)在原发性肝癌检测中的意义。方法设定原发性肝癌组52例,肝硬化组36例,健康对照组103例,测定各组的AFU、5′NT和γ-GGT水平,单独测定甲胎蛋白(AFP)在原发性肝癌组的水平。结果 52例原发性肝癌患者中,AFP>6.7 U/mL阳性者为37例,检出率为71.15%,而AFU、5′NT和γ-GGT联合检出阳性者为43例,阳性率为82.69%。原发性肝癌组的AFU、5′NT和γ-GGT水平比单检AFP水平敏感性高。结论 AFU、5′NT和γ-GGT联合检测可弥补AFP低水平的不足,是一个诊断原发性肝癌的有效血清酶学指标。AFU、5′NT和γ-GGT对原发性肝癌的诊断敏感性、特异性各有所长,联合应用可优势互补,阳性率可显著提高,对临床诊断及判断病情,疾病的转归有重要意义。
Objective To investigate the significance of AFU,5＇NT,and γ-GGT detection in primary hepatic carcinoma.Methods AFU,5＇NT,and γ-GGT were detected in 52 cases of primary hepatic carcinoma,36 cases of cirrhosis,103 cases of health.AFP was independently detected in liver cancer group Results in 52 cases of primary hepatic cancer,37 cases were positive AFP（〉6.7 U/mL）,the detection rate was 71.15%.The co-detection of FU,5＇NT,and γ-GGT was positive in 43 cases,the detection rate was 82.69%.Co-detecded AFU,5＇NT,and γ-GGT level in primary hepatic carcinoma group was more sensitivity than AFP.Conclusion Combined detecting AFU,5＇NT and γ-GGT can compensate the deficiency of low-level AFP,which is a serum enzyme indicators in dagnosing primary hepatic carcinoma.The co-detection has important significance in dagnosing primary hepatic carcinoma and estimating the disease condition and outcome.
出处
《检验医学与临床》
CAS
2010年第24期2698-2698,2701,共2页
Laboratory Medicine and Clinic
