摘要
目的：探讨鼻腔鼻窦恶性黑色素瘤的诊断和治疗效果。方法：１７例恶性黑色素瘤标本，采用免疫组化进行ＨＭＢ４５，Ｓ－１００、Ｖｉｍｅｎｔｉｎ、ＣＥＡ、Ｋｅｒａｔｉｎ抗体联合标记，所有病例分别采用手术、手术加放疗、手术加放疗和化疗进行治疗。结果：ＨＭＢ４５阳性率１７／１７，Ｓ－１００１５／１７，Ｖｉｒｍｅｎｔｉｎ８／１７，而ＣＥＡ、Ｋｅｒａｔｉｎ均为阴性。随访１３例，３年、５年生存率分别为５３％、３１％。结论：免疫组化检查对本病诊断和鉴别诊断有较大帮助，ＨＭＢ４５为恶性黑色素瘤特异性标记物；早期诊断、根治性手术切除能提高本病生存率。
Objective: To explore the diagnosis and treatment of malignant melanoma in the nasal cavity and paranasal sinuses. Methods: An immunohistochemical technique was adopted for 17 cases. The labelled antibodies used as HMB45, S-100, Vimentin, CEA and Keratin were specific. All cases were treated with simple surgery、 surgery with radiotherapy or combined therapy. Results: Positive HMB45, S-100 and Vimentin staining were shown in 17,15 and 8 cases respectively, while none showed immunoreactivity with CEA or Keratin. 13 cases were followed up, the three-, and five year survival rates were 53% and 31% respectively. Conclusion: Immunohistochemistry is a good help for diagnosis and differentiation of this disease. HMB45 may be a specific marker for malignant melanoma. Early diagnosis and radical operation can improve the survival rate.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1999年第1期32-34,I000,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
