摘要
目的评价短期锰接触对机体生长发育造成的毒性影响。方法 36只SD大鼠随机分为3组,第1组为对照组,供用未加锰的新鲜蒸馏水,第2、3组为实验组,分别供用不同浓度(0.5和5.0g/L)的氯化锰,60d后,检测大鼠锰接触后脏器系数(内脏/体比)、血清和脑匀浆的一氧化氮合酶(NOS)、超氧化物岐化酶(SOD)活力,以及中脑黑质区神经胶质细胞纤维酸蛋白(GFAP)免疫反应阳性胶质细胞的改变。结果与对照组相比,锰接触60d后高、低剂量组大鼠的脏器系数无明显改变;大鼠血清和脑匀浆中的NOS比对照组明显升高,而SOD活力则明显降低;在中脑黑质,GFAP免疫反应阳性胶质细胞反应强度、细胞数密度(GV)和反应阳性产物的相对吸光度值(A),高、低剂量组大鼠均比对照组显著升高。结论短期的锰接触对大鼠的各脏器系数影响不大;随着锰接触剂量的增加,血清和脑匀浆中的NOS则明显升高,而SOD活力明显降低;锰接触会对中脑黑质星形胶质细胞产生明显的毒性损害。
[Objective]To grasp morbidity level and the epidemiological characteristics of mumps in Shenyang City,and provide evidence for mumps prevention plan.[Methods]Descriptive epidemiology was adopted to analyze the mumps epidemic situation in Shenyang City.[Results]The annual average incidence of mumps in 5420 /100 000 in Shenyang during 2005-2009,urban incidence was 5917 /100 000,and 4976 /100 000 in rural area（P 001）.Male incidence was 6622 /100 000,and 4187 /100 000 of female incidence（P 0.01）,male to female was 162：1.The cases number from April to July account for 44.32% of the whole year number.The student,kindergartens and scattered children totally accounted for 90.17% 。The age group of 10 ～ 14 year old accounted for 32.46%。[Conclusion]The epidemiological characteristics of mumps in Shenyang City were male incidence higher than that of female,obvious occupational characteristics and higher incidence among adolescent.It is necessary to strengthen the organizational leadership of infectious disease control and prevention,to implement control measures,to carry out health promotion and health education,to improve health knowledge and awareness of prevention and control,to strengthen the training of professionals,to improve technology levels and emergency response capabilities of professionals,to strengthen monitoring and early warning,and to timely detect of epidemic situation in schools and nurseries of Shenyang City
出处
《职业与健康》
CAS
2010年第24期2901-2904,共4页
Occupation and Health
