摘要
目的观察肿瘤患者血清ＴＮＦ－α的变化及临床意义。方法应用放射免疫测定法对２０例健康对照者和７０例肿瘤患者进行了血清ＴＮＦ－α含量测定。结果对照组血清ＴＮＦ－α的含量较低，肿瘤患者明显升高（Ｐ＜０．０１）；肿瘤转移和／或复发时无进一步上升，而肿瘤合并胸腹水和恶液质时ＴＮＦ－α上升明显。结论肿瘤患者血清的ＴＮＦ－α水平明显高于对照组，随着肿瘤的局部控制及消退，体内ＴＮＦ－α含量呈下降趋势，因此ＴＮＦ－α含量的变化对肿瘤患者病情变化及预后的判定，具有一定的参考价值。
Objective To detect the changes of tumor necrosis factor-α in tumor patients.Methods The content of TNF-α in serum was determined by radioimmunoassay (RIA) in 20 controls,70 patients with malignant tumor.Results The content of TNF-α in serum in control group was lower significantly than that of tumor group (P< 0.01 ). The level of TNF-α in cancer patients decreased after operation or radiotherapy.They did not show further increasing of the content of TNF-α in recurrent or/and metastatic patients.When the cancer patients with pleural effusion or ascites,the level of TNF-α showed further increasing.Conclusions The level of TNF-α in serum of cancer patients was higher than that of control group.There was a increasing trend of the level of TNF-α in recurrent or/and metastatic patients,but did not show significantly difference with that of tumor group.Therefore,the level of TNF-α in serum of cancer patients may be helpful for estimating the development of disease and prognosis for cancer patients.
出处
《中国肿瘤临床与康复》
1999年第3期15-16,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肿瘤坏死因子
预后
肿瘤
Tumor Necrosis Factor-α(TNF-α) Prognosis
