摘要
为了比较二氯化锶(89SrCl2)和89SrCl2联合唑来膦酸治疗多发性骨转移癌的疗效,将80例多发性骨转移癌患者,随机分为A组(单独使用放射性核素89SrCl2治疗)和B组(89SrCl2联合唑来膦酸治疗)各40例,观察治疗后骨痛缓解和生活质量的情况,比较转移病灶骨代谢的变化和血液毒性反应。结果显示,A组治疗后总有效率72.5%(29/40),B组总有效率77.5%(31/40),χ2=4.24,P<0.05。A组生活质量改善率65.0%(26/40),B组改善率82.5%(33/40),χ2=7.49,P<0.01。两组转移病灶骨代谢治疗后有效率分别为45.0%和67.5%,P<0.05;血液毒性反应分别为22.5%和27.5%,P>0.05。初步研究结果提示,89SrCl2联合唑来膦酸治疗多发骨转移癌,可以增加止痛效果、提高患者生存质量,而不增加毒副反应,是一种较好的联合治疗方法。
The objective of this study was to compare the clinical effect of treating multiple osseous metastasis between 89SrCl2 and the association of 89SrCl2 and zoledronic acid. Eighty cases of multiple osseous metastasis were divided into two groups randomly, the group A was solely applied adionuclide 89SrCl2 and the group B was used the association of 89SrCl2 and zoledronic acid, and the condition of remission of bone ache and quality of life after the treatment were observed to compare the changing of bone metabolism of metastatic lesion and the reaction of hematological toxicity. The effective rate of relieving pain of group A was 72.5%（29/40）, the effective rate of relieving pain of group B was 77.5%（31/40,χ2=4.24, P0.05）. The effective rate of improving of group A was 65.0%（26/40）. The effective rate of improving of group B was 82.5%（33/40,χ2=7.49, P0.01）. The effective rates of bone metabolism of metastatic lesion after treatment were 45.0% and 67.5% （P0.05） in the group A and group B, respectively, and the hematological toxicities were 22.5% and 27.5%, respectively （P0.05）. Applying the association of 89SrCl2 and zoledronic acid in the treatment of multiple osseous metastasis can increase the analgesic effect and improve of the quality of life furthermore, but not adding toxic and side reactions, so it is a better method of associated treatment.
出处
《中华肿瘤防治杂志》
CAS
2010年第19期1584-1585,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
骨肿瘤/治疗
锶放射性同位素
二膦酸盐类
肿瘤
多原发性
bone neoplasms/therapy
strontium radioisotopes
diphosphonates
neoplasms
multiple primary
