摘要
目的:探讨检测C-反应蛋白(CRP)和中性粒细胞表面CD64在小儿腹泻的鉴别诊断和疗效判断中的价值。方法:将60例患儿按腹泻的类型分为细菌性腹泻组、病毒性腹泻组和非感染性腹泻组,分别检测每位患儿治疗前后的CRP和CD64。结果:细菌性腹泻组的CRP和CD64明显高于病毒性腹泻组、非感染性腹泻组,差异有统计学意义(P<0.05),治疗后CRP和CD64明显较治疗前下降(P<0.05);病毒性腹泻组与非感染性腹泻组的CRP和CD64比较差异无统计学意义(P>0.05)。CRP诊断细菌性腹泻的敏感性为91%,特异性为80%;CD64的敏感性为87%,特异性为92%。结论:联合检测CRP和CD64有助于小儿腹泻的早期诊断、鉴别诊断和对抗菌药物疗效的判断。
Objective：To investigate the effect of detection of C - reactive protein （CRP） and neutrophil surface CD64 in the differential diagnosis and therapeutic evaluation of infantile diarrhea. Methods： The 60 patients were divided into three groups：bacterial diarrhea group, viral diarrhea group and non - infectious diarrhea group. The CRP and CDu of each children were detected before and after treatment. Results：The CRP and CD64 in the bacterial diarrhea group had a statistical difference comparing with viral diarrhea group, non - infectious diarrhea group and the after treatment group （ P 〈 0. 05 ）. The CRP and CD64 in the viral diarrhea group had non statistical difference comparing with non - infectious diarrhea group （ P 〉 0. 05 ）. The sensitivity and specificity of CRP value were 91% and 80%, while the sensitivity and specificity of CD64 value were 87% and 92%. Conclusion ：The detection of CRP and CD64 contribute the early diagnosis ,the differential diagnosis and the observation of anti - infection effect for bacterial diarrhea.
