摘要
复合药物微粒作为新型的药物载体,因具有较好的超细小的粒径、生物相容性及良好的体内分布而受到广泛的关注。复合药物微粒可包载蛋白质、多肽、基因等大分子药物,还可实现缓释、控释、靶向给药等,使药物在病灶处释药,具有减少给药剂量、延长作用时间及降低机体损伤等优点。文章简要介绍利用超临界流体膨胀技术、流化床技术、超临界流体辅助渗透技术、超临界流体反溶剂技术制备药物缓释复合微粒的研究现状及应用前景。
The composite drug micro-particle as new drug carrier attracts much attention because of its super small particle size, biologic consistent character and perfect bio-distribution. Multi-compound drug micro-particle can not only load macromolecular drug such as protein, peptide and gene, but also make slow -release, controlled -release and targeting drug come true. These cause drug to release in the lesions with some advantages, such as reducing dosage, prolonging reaction time and decreasing body injuries. This paper gives a brief description of the present situation and the potential applications of the preparation of multi -compound drug micro -particle by using the supercritical fluid solutions, the fluidized-bed coating, the technology of supercritical fluid accessorial infiltration and the supercritical antisolvent process.
关键词
超临界流体
复合药物微粒
药物微胶囊
脂质体
supercritical fluid
multi-compound drug micro-particle
drug microcapsule
liposome
