摘要
RLRs - the retinoic acid-inducible gene-I （RIG-I） and melanoma differentiation-associated gene 5 （MDA5） - are novel cytoplasmic RNA helicases that recognize viral RNA present within the cytoplasm [ 1 ]. The identification of the MAVS （mitochondrial antiviral signaling） adaptor protein as a member of the RIG-I-like receptors （RLRs） signaling pathway links the mitochondria to the mammalian antiviral defense system [2].
