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多西他赛联合5-氟尿嘧啶、顺铂治疗晚期复治食管癌疗效观察 被引量:11

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摘要 目的探讨多西他赛联合5-氟尿嘧啶、顺铂组成的化疗方案治疗晚期复治食管癌的临床疗效和安全性。方法将77晚期复治食管癌患者随机分为两组,治疗组采用多西他赛联合顺铂、5-氟尿嘧啶方案化疗,对照组采用顺铂、5-氟尿嘧啶方案化疗,21 d为一周期,连用2个周期后评价疗效。结果治疗组的有效率、疾病控制率均高于对照组,但两组仅疾病控制率比较有统计学差异(P<0.05);治疗组骨髓抑制发生例数多于对照组(P<0.05),其余不良反应相似。结论多西他赛联合顺铂、5-氟尿嘧啶方案治疗晚期复治食管癌有效率较高,不良反应可耐受,可作为老年食管癌患者的首选化疗方案。
出处 《山东医药》 CAS 北大核心 2010年第37期69-70,共2页 Shandong Medical Journal
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