摘要
目的观察食管、贲门癌切除术后辅助化疗的影响及耐受性。方法 65例食管、贲门癌病人术后3～4周施行辅助化疗4～6周期,于同期未辅助化疗者对比。结果全组无严重并发症,无死亡病例。均有不同程度恶心、呕吐。白细胞降低者37例(56.9%),肝功能异常者14例(21.5%),脱发49例(75.4%),无Ⅳ级毒副反应发生。1、2、3、4年生存率治疗组分别89.23%、75.38%、62.0%、52.30%,对照组分别81.48%、61.11%、48.14%、35.18%,(P<0.05)。结论食管、贲门癌术后适当剂量辅助化疗,毒副反应轻微,耐受性良好,对病人生活质量影响短暂,可使生存受益。
Objective To oberseve the effect and endurance of adjuvant chemotherapy after esophageal-cardiac carcinoma-ectomy.Methods 65 cases of esophagea or cardiac carcinoma are takend the adjuvant chemotherapy for 4-6 periods in 3-4 weeks after operation,and compared with no adjuvant chemotherapy in the corresponding period.Results No serious complications and death happened but nausea and vomiting of different degree have taken place.There are 37 cases（56.9%）WBC reduce;14 cases（21.5%） liver function abnormal;49 cases（75.4%） trichomadesis,The survival rate of 1,2,3,4 years after operation is respectively 89.23%,75.38%,62%,52.30% in research group and respectively 81.48%,61.11%,48.14%,35.18% in contrast group（P0.05）.Conclusion Suitable adjuvant chemotherapy after operation of esophageal and cardiac carcinoma may benefi t from survival and its harmful effects are light,endurance better and shorter
出处
《当代医学》
2010年第26期122-123,共2页
Contemporary Medicine
关键词
食管
贲门癌
手术切除
辅助化疗
Esophageal-cardiac
Carcinoma
Resection
Adjuvant themotheray
