摘要
对服用雷公藤治疗结缔组织疾病引起闭经的９例育龄期妇女进行了性激素水平的对比测定，同时Ｂ超探查子宫情况。结果，用药组９例ＦＳＨ（卵泡刺激素），ＬＨ（黄体生成素）分别为８１１６±４４２５ｍＵ／Ｌ，８７８４±６７１０ＩＵ／Ｌ，明显高于未用药组８６７±３８１ｍＵ／Ｌ和１０９６±１５９０ＩＵ／Ｌ（Ｐ＜０００１和Ｐ＜００５）。Ｅ２（雌二醇），ＰＲＬ（催乳素）分别为２２３０±２９６２ｐｍｏｌ／Ｌ，１２６３±４７３μｇ／Ｌ，明显低于未用药组５８０８８±４７０８ｐｍｏｌ／Ｌ，１９５７±１１９４μｇ／Ｌ（Ｐ＜００５）。用药组６例伴有子宫萎缩，未用药组正常，其中用药组７例符合高促性腺性闭经，提示卵巢功能减退或衰竭。因此，育龄期妇女使用该药时应慎重。
Sex hormone levels of 9 fertile women with connective tissue disease with Tripterygium wilfordii induced amenorrhea and 9 SLE patients without taking Tripterygium wilfordii as control were tested. The levels of FSH and LH in the treatment group(81 16±44 25mU/L,87 84±67 10 IU/L) were higher than those in the control group(8 67±3 81mU/L,10 96±15 90IU/L)(P< 0 001,P< 0 05). The levels of E2 and PRL in the treatment group(22 30±29 62pmol/L, 12 63±4 73μg/L) were lower than those in the control group(580 88±470 8pmol/L,19 57±11 94μg/L)(P< 0 05). 6 cases in the treatment group showed atrophy of uterus by B ultrasonic examination. It is the authors opinion that when this medicine is used in clinical practice, we should pay attention to it.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1999年第3期163-164,共2页
Journal of Clinical Dermatology
